Sebastian Bruchmann

About

I have a strong interest in microbial functional genomics and am using different sequencing-based methods to understand how the human pathogen Klebsiella pneumoniae interacts with the immune system, in particular macrophages.

Work

University of Cambridge

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Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

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University of Cambridge

|

Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

→

University of Cambridge

|

Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

→

Wellcome Trust Sanger Institute

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Postdoctoral Fellow

United Kingdom of Great Britain and Northern Ireland

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Helmholtz Centre for Infection Research

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Postdoctoral Researcher

Germany

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Publications

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

Proceedings of the National Academy of Sciences

journal-article

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

Proceedings of the National Academy of Sciences

journal-article

PowerBacGWAS: a computational pipeline to perform power calculations for bacterial genome-wide association studies

Communications Biology

journal-article

PowerBacGWAS: a computational pipeline to perform power calculations for bacterial genome-wide association studies.

Communications biology

journal-article

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection

The ISME Journal

journal-article

Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.

PLoS genetics

journal-article

Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen

PLOS Genetics

journal-article

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella.

Pathogens and disease

journal-article

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella

Pathogens and Disease

journal-article

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella

preprint

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection.

The ISME journal

journal-article

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study

Microbial Genomics

journal-article

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study

Microbial Genomics

journal-article

Spatiotemporal control of FlgZ activity impacts Pseudomonas aeruginosa flagellar motility.

Molecular microbiology

journal-article

BACTOME-a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates.

Nucleic acids research

journal-article

Importance of flagella in acute and chronic Pseudomonas aeruginosa infections.

Environmental microbiology

journal-article

Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

journal-article

Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation

Environmental Microbiology

journal-article

Elucidation of sigma factor-associated networks in Pseudomonas aeruginosa reveals a modular architecture with limited and function-specific crosstalk

PLoS pathogens

journal-article

Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of ampc

Antimicrobial Agents and Chemotherapy

journal-article

Quantitative contributions of target alteration and decreased drug accumulation to pseudomonas aeruginosa fluoroquinolone resistance

Antimicrobial Agents and Chemotherapy

journal-article

Radically different phylogeographies and patterns of genetic variation in two European brown frogs, genus Rana

Molecular Phylogenetics and Evolution

journal-article