Sebastian Bruchmann

About

I have a strong interest in microbial functional genomics and am using different sequencing-based methods to understand how the human pathogen Klebsiella pneumoniae interacts with the immune system, in particular macrophages.

Work

University of Cambridge
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Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

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University of Cambridge
|

Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

→

University of Cambridge
|

Senior Research Associate

United Kingdom of Great Britain and Northern Ireland

→

Wellcome Trust Sanger Institute
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Postdoctoral Fellow

United Kingdom of Great Britain and Northern Ireland

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Helmholtz Centre for Infection Research
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Postdoctoral Researcher

Germany

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Publications

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

PowerBacGWAS: a computational pipeline to perform power calculations for bacterial genome-wide association studies

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Communications Biology

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PowerBacGWAS: a computational pipeline to perform power calculations for bacterial genome-wide association studies.

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Communications biology

Summary

journal-article

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection

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The ISME Journal

Summary

journal-article

Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.

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PLoS genetics

Summary

journal-article

Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen

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PLOS Genetics

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journal-article

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella.

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Pathogens and disease

Summary

journal-article

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella

Published by

Pathogens and Disease

Summary

journal-article

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella

Summary

preprint

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection.

Published by

The ISME journal

Summary

journal-article

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study

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Microbial Genomics

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Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study

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Microbial Genomics

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Spatiotemporal control of FlgZ activity impacts Pseudomonas aeruginosa flagellar motility.

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Molecular microbiology

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journal-article

BACTOME-a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates.

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Nucleic acids research

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Importance of flagella in acute and chronic Pseudomonas aeruginosa infections.

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Environmental microbiology

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journal-article

Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa

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Antimicrobial Agents and Chemotherapy

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Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation

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Environmental Microbiology

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journal-article

Elucidation of sigma factor-associated networks in Pseudomonas aeruginosa reveals a modular architecture with limited and function-specific crosstalk

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PLoS pathogens

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journal-article

Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of ampc

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Antimicrobial Agents and Chemotherapy

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Quantitative contributions of target alteration and decreased drug accumulation to pseudomonas aeruginosa fluoroquinolone resistance

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Antimicrobial Agents and Chemotherapy

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journal-article

Radically different phylogeographies and patterns of genetic variation in two European brown frogs, genus Rana

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Molecular Phylogenetics and Evolution

Summary

journal-article